ABSTRACT
With the deepening of the concept of precise and minimally invasive treatment for liver cancer, local thermal ablation is playing an increasingly important role in the comprehensive treatment of liver cancer and is becoming a new way to kill tumor cells. It can not only directly inactivate tumor cells, but also induce specific antitumor immunity. However, the immune response induced by thermal ablation is often at a low level, which is not sufficient to prevent tumor progression. Thermal ablation combined with transhe-patic arterial chemoembolization (TACE) and immunotherapy can significantly improve antitumor immunity, delay the recurrence and metastasis of tumors, and provide new ideas for the treatment of liver cancer, especially advanced liver cancer. It has a broad applica-tion value. In this review, the progress of thermal ablation in immunotherapy of hepatocellular carcinoma is reviewed.